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| http://dx.doi.org/10.1016/j.jdcr.2023.10.014 | DOI Listing |
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Enhancement of detoxification of xenobiotic aromatic amine dyes by N-acetyltransferase 1 (NAT1) enzyme on human keratinocytes cells through structural modification.
Environ Toxicol Pharmacol
December 2024
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Lower Kent Ridge Road, 4 Science Drive 2, 117544, Singapore. Electronic address:
The metabolic conversion of aromatic amines to N-acetylated forms in skin and keratinocytes depends on N-acetyltransferase-1 (NAT1). Common hair color ingredient such as para-phenylenediamine (PPD) causes allergic contact dermatitis. We explored how different electronic substituents on PPD aided NAT1 enzyme biotransform oxidative arylamine (AA) compounds G1-G13 by N-acetylation, NAT-1 activity assays, metabolism, and in vitro clearance investigations in human keratinocytes, while identifying NAT-1 protein levels by Western blot and qRT-PCR.
View Article and Find Full Text PDFAllergic Contact Dermatitis Associated With Men's Personal Care Products: A Review of Allergens.
Dermatitis
November 2024
Affiliated Dermatology, Mesa, Arizona, USA.
Personal care product usage is becoming increasingly prevalent among men due to evolving attitudes surrounding appearance, aging, and masculinity. Given the specific characteristics of male skin compared with female skin and varying product use between males and females, the occurrence of allergic contact dermatitis (ACD) due to men's personal care products needs to be better characterized. The purpose of this review was to identify specific product types and ingredients causing ACD in males.
View Article and Find Full Text PDFAllergic Contact Dermatitis Reaction to Permanent Tattoo Containing Paraphenylenediamine: A Case Report.
Case Reports Immunol
September 2024
Mid-Island Allergy Group, Plainview, New York, USA.
Paraphenylenediamine (PPD) is a well-known culprit allergen in the literature and clinical practice. Although this has been described in temporary tattoos, the definite implication of PPD in permanent tattoos has not been described. We report a patient who developed severe allergic contact dermatitis (ACD) requiring skin grafting after receiving a permanent tattoo with ink containing PPD.
View Article and Find Full Text PDFPatch Testing in Allergic Contact Dermatitis.
J Nepal Health Res Counc
March 2024
Tribhuvan University Teaching Hospital, Kathmandu.
Background: Allergic contact dermatitis is one of the most common forms of skin diseases that require medical intervention. Appropriate detection of allergens by patch test and accurate avoidance of them is the key to management. The objective of this study is to determine the types and frequency of allergens responsible for Allergic contact dermatitis in a tertiary hospital of Nepal.
View Article and Find Full Text PDFp-phenylenediamine induced depigmentation on scalp and patch test site: A case report.
Contact Dermatitis
August 2024
Department of Dermatology, Venereology and Leprosy, JSS Medical College and Hospital, JSS Academy of Higher Education (Deemed to be University), Mysuru, Karnataka, India.
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