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Exploring the UVB-protective efficacy of melanin precursor extracted from marine imperfect fungus: Featuring characterization and application studies under in vitro conditions.
Int Microbiol
June 2018
Microbiology Division, CSIR-CLRI, Adyar, Chennai 20, Tamil Nadu, India.
The present study explores the production, characterization, and application of a potentially stable melanin precursor from marine imperfect non-spore-forming Aspergillus nidulans sp. strain SG 28. Growth of the culture in artificial seawater with galactose and monosodium glutamate, pH at 7.
View Article and Find Full Text PDFPurpose: Technetium-99m is a radioactive tracer that emits gamma rays. Its half-life time is 6 h. Similar to other ionizing radiations, the main mechanism of radiation-induced effects is initiated through the production of reactive oxygen species (ROS).
View Article and Find Full Text PDFRapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine.
Am J Physiol Gastrointest Liver Physiol
May 2016
Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee
The goals of this study were to evaluate the effects of ionizing radiation on apical junctions in colonic epithelium and mucosal barrier function in mice in vivo. Adult mice were subjected to total body irradiation (4 Gy) with or without N-acetyl-l-cysteine (NAC) feeding for 5 days before irradiation. At 2-24 h postirradiation, the integrity of colonic epithelial tight junctions (TJ), adherens junctions (AJ), and the actin cytoskeleton was assessed by immunofluorescence microscopy and immunoblot analysis of detergent-insoluble fractions for TJ and AJ proteins.
View Article and Find Full Text PDFAnti-UV activity of newly-synthesized water-soluble azulenes.
In Vivo
May 2013
Josai University, Sakado, Saitama 350-0295, Japan.
Background: We have previously reported that azulene-related compounds can protect cells from UV-induced cytotoxicity. However, due to their high water insolubility, their anti-UV activity could not be accurately determined. In the present study, we newly-synthesized a total of nine derivatives with higher water solubility, and re-investigated their anti-UV activity.
View Article and Find Full Text PDFMelanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer.
Int J Radiat Oncol Biol Phys
December 2010
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Purpose: Protection of bone marrow against radiotoxicity during radioimmunotherapy and in some cases external beam radiation therapy such as hemi-body irradiation would permit administration of significantly higher doses to tumors, resulting in increased efficacy and safety of treatment. Melanin, a naturally occurring pigment, possesses radioprotective properties. We hypothesized that melanin, which is insoluble, could be delivered to the bone marrow by intravenously administrated melanin-covered nanoparticles (MNs) because of the human body's "self-sieving" ability, protecting it against ionizing radiation.
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