Electrocardiographic parameters and serum concentrations of potassium, sodium, calcium (total and ionized) and magnesium in 6 essentially healthy men, aged 30-45 years, were measured before, during and after 120-day head-down tilt at -4.5 degrees. A close correlation was demonstrated between T-wave depression and serum concentrations of potassium (direct correlation) and calcium and magnesium (inverse correlation). No consistent changes in the sodium content during the 120-day test were seen. In spite of electrolyte changes in blood induced by head-down tilt, ECG variations showed minor hypokalemia that was not followed by any clinical symptoms. These data can be used to evaluate the status of healthy people exposed to prolonged hypokinesia and to develop adequate prophylactic measures.
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