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Lung cancer organoid-based drug evaluation models and new drug development application trends.
Transl Lung Cancer Res
December 2024
Department of Biomedical Engineering, Gachon University, Seongnam, Republic of Korea.
Lung cancer is a malignant tumor with high incidence and mortality rates in both men and women worldwide. Although anticancer drugs are prescribed to treat lung cancer patients, individual responses to these drugs vary, making it crucial to identify the most suitable treatment for each patient. Therefore, it is necessary to develop an anticancer drug efficacy prediction model that can analyze drug efficacy before patient treatment and establish personalized treatment strategies.
View Article and Find Full Text PDFOrganoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment.
Drug Resist Updat
January 2025
Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, China; The Biobank, Scientific Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China. Electronic address:
Article Synopsis
- Organoids were created from a patient's primary tumor and metastatic lymph nodes, accurately mirroring the tumor's characteristics.
- Drug testing on these organoids showed distinct differences in how they responded to treatments based on their origin (primary vs. metastatic).
- This personalized approach to using organoids aids in making informed treatment decisions for gastric cancer, potentially improving patient outcomes.
Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.
Nat Commun
December 2024
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.
View Article and Find Full Text PDFOrganoid-based precision medicine in pancreatic cancer.
United European Gastroenterol J
November 2024
Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.
Pancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer-related deaths worldwide. Despite advances in precision oncology in other malignancies, treatment of PDAC still largely relies on conventional chemotherapy. Given the dismal prognosis and heterogeneity in PDAC, there is an urgent need for personalized therapeutic strategies to improve treatment response.
View Article and Find Full Text PDFProspective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction - feasibility and real world experience.
Exp Hematol Oncol
November 2024
Department of Urology, Ulm University Hospital, Ulm, Germany.
Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landscape and variable response to systemic therapy. In recent years, patient-derived organoids (PDOs) emerged as a novel tool to model primary tumors with higher resemblance than conventional 2D cell culture approaches. However, the potential of organoids to predict therapy response in a clinical setting remains to be evaluated.
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