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| http://dx.doi.org/10.1016/j.asjsur.2023.11.151 | DOI Listing |
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A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state.
Breast Cancer Res
December 2024
Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Background: Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype. From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre-malignant properties, including an aberrant epigenetic program that enables continued proliferation and acquisition of genetic changes.
View Article and Find Full Text PDFFibromatosis-Like Metaplastic Carcinoma of the Breast: A Challenging Diagnosis With Potential Pitfalls.
Int J Surg Pathol
December 2024
Breast Department, KK Women's and Children's Hospital, Singapore.
Fibromatosis-like metaplastic carcinoma (FLMC) is a rare subtype of metaplastic carcinoma of the breast. Diagnosing this entity poses significant challenges, particularly in core biopsies due to limited sampling and overlap with benign spindle cell lesions such as nodular fasciitis and fibromatosis. We present an example of FLMC in an asymptomatic middle-aged woman.
View Article and Find Full Text PDFNovel models based on machine learning to predict the prognosis of metaplastic breast cancer.
Breast
December 2024
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China. Electronic address:
Background: Metaplastic breast cancer (MBC) is a rare and highly aggressive histological subtype of breast cancer. There remains a significant lack of precise predictive models available for use in clinical practice.
Methods: This study utilized patient data from the SEER database (2010-2018) for data analysis.
Invasive Squamous Cell Carcinoma of the Nipple: Case Report With Literature Review.
Am J Dermatopathol
November 2024
Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT.
Article Synopsis
- A 73-year-old woman experienced bloody discharge and skin thickening in her right breast, prompting concerns for Paget disease.
- A skin punch biopsy revealed high-grade infiltrating carcinoma with squamous features, ruling out other types like metaplastic carcinoma due to her medical history.
- A lumpectomy confirmed invasive squamous cell carcinoma of the nipple, linked to Bowen disease, emphasizing the need for awareness of rare diagnoses in patients with prior breast cancer.
Transdifferentiation of Secretory Carcinoma to Metaplastic Carcinoma at Metastatic Site.
Int J Surg Pathol
December 2024
James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Secretory carcinoma is a rare breast tumor driven by fusion. It has characteristic morphologic features and identification of these tumors is critical as these patients may benefit from TRK inhibitors. Morphologic shift upon treatment has not been reported in secretory carcinoma or other -driven tumors.
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