The purpose of this narrative review is to provide a comprehensive overview of current research on heart-gut cross talk and its implications for cardiovascular disease. To uncover relevant preclinical and clinical research examining heart-gut cross talk, a thorough literature search was undertaken utilising electronic databases. The chosen publications were critically examined, and major findings were synthesised to offer a thorough perspective on the subject. We want to synthesise the most recent study findings, explain the underlying mechanisms, and provide potential treatment techniques. By exploring bidirectional connection between the heart and the gut, we shed light on novel future options for the prevention and treatment of cardiovascular diseases. The heart-gut cross talk is an exciting field of study with implications for cardiovascular disease. Understanding the complex connection between the heart and the gastrointestinal tract may lead to the development of novel therapeutic targets and therapies for the prevention and management of cardiovascular diseases. Future research should concentrate on identifying the specific processes driving this crosstalk as well as assessing the efficacy of therapies targeting the gut microbiota and the gut-brain axis in improving cardiovascular outcomes.
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http://dx.doi.org/10.1016/j.ihj.2023.12.003 | DOI Listing |
Indian Heart J
May 2024
Department of Cardiac Surgery, Narayana Health, India. Electronic address:
Front Immunol
June 2022
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Trauma/hemorrhagic shock followed by resuscitation (T/HS-R) results in multi-system inflammation and organ dysfunction, in part driven by binding of damage-associated molecular pattern molecules to Toll-like Receptor 4 (TLR4). We carried out experimental T/HS-R (pseudo-fracture plus 2 h of shock followed by 0-22 h of resuscitation) in C57BL/6 (wild type [WT]) and TLR4-null (TLR4) mice, and then defined the dynamics of 20 protein-level inflammatory mediators in the heart, gut, lung, liver, spleen, kidney, and systemic circulation. Cross-correlation and Principal Component Analysis (PCA) on data from the 7 tissues sampled suggested that TLR4 samples express multiple inflammatory mediators in a small subset of tissue compartments as compared to the WT samples, in which many inflammatory mediators were localized non-specifically to nearly all compartments.
View Article and Find Full Text PDFDiabetes
October 2012
Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP administration on appetite-regulating hormones and subjective ratings of hunger and satiety in 10 healthy volunteers.
View Article and Find Full Text PDFIntensive Care Med
March 2005
Howard Florey Institute, University of Melbourne, Parkville, VIC, Australia.
Objective: To study the effect of epinephrine (EPI) infusion on vital organ blood flow and metabolic variables during sepsis.
Design And Setting: Randomised placebo-controlled animal trial in an animal laboratory.
Animals: Seven merino cross-ewes.
Chest
September 2003
Howard Florey Institute, Parkville, Melbourne, Australia.
Objectives: To develop a nonlethal model of hyperdynamic sepsis, and to measure vital organ blood flows in this setting.
Design: Randomized crossover animal study.
Setting: Animal laboratory of university-affiliated physiology institute.
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