Cardiovascular diseases and the heart-gut cross talk.

Indian Heart J

Department of Cardiac Surgery, Narayana Health, India. Electronic address:

Published: May 2024

AI Article Synopsis

  • The narrative review explores the emerging research on the communication between the heart and gut and its relevance to cardiovascular diseases.
  • The authors conducted a thorough literature review, critiquing preclinical and clinical studies to synthesize key findings and mechanisms at play in heart-gut interactions.
  • Future investigations should focus on the specific processes involved in this cross talk and the potential of treatments targeting gut health and the gut-brain connection for better cardiovascular outcomes.

Article Abstract

The purpose of this narrative review is to provide a comprehensive overview of current research on heart-gut cross talk and its implications for cardiovascular disease. To uncover relevant preclinical and clinical research examining heart-gut cross talk, a thorough literature search was undertaken utilising electronic databases. The chosen publications were critically examined, and major findings were synthesised to offer a thorough perspective on the subject. We want to synthesise the most recent study findings, explain the underlying mechanisms, and provide potential treatment techniques. By exploring bidirectional connection between the heart and the gut, we shed light on novel future options for the prevention and treatment of cardiovascular diseases. The heart-gut cross talk is an exciting field of study with implications for cardiovascular disease. Understanding the complex connection between the heart and the gastrointestinal tract may lead to the development of novel therapeutic targets and therapies for the prevention and management of cardiovascular diseases. Future research should concentrate on identifying the specific processes driving this crosstalk as well as assessing the efficacy of therapies targeting the gut microbiota and the gut-brain axis in improving cardiovascular outcomes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143509PMC
http://dx.doi.org/10.1016/j.ihj.2023.12.003DOI Listing

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  • Future investigations should focus on the specific processes involved in this cross talk and the potential of treatments targeting gut health and the gut-brain connection for better cardiovascular outcomes.
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