AI Article Synopsis
- Local tumor radiotherapy changes the types and behaviors of myeloid-derived suppressor cells (MDSCs), which can negatively impact the effectiveness of radiation treatments.
- New research indicates that RNA mA modifications play a significant role in both the immune response against tumors and how tumors react to radiation therapy.
- The study explores how RNA mA modifications affect the immune environment in tumors altered by radiation and suggests targeting these modifications could enhance the success of radiotherapy.
Article Abstract
Emerging evidence suggests that local tumor radiotherapy reshapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microenvironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA mA modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenvironment. We discuss potential therapeutic interventions targeting mA machinery to improve radiotherapy response.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751059 | PMC |
| http://dx.doi.org/10.1016/j.medj.2023.09.001 | DOI Listing |
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