The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2533/chimia.2022.1039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3D-Printed Myocardium-Specific Structure Enhances Maturation and Therapeutic Efficacy of Engineered Heart Tissue in Myocardial Infarction.
Adv Sci (Weinh)
January 2025
Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Despite advancements in engineered heart tissue (EHT), challenges persist in achieving accurate dimensional accuracy of scaffolds and maturing human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), a primary source of functional cardiac cells. Drawing inspiration from cardiac muscle fiber arrangement, a three-dimensional (3D)-printed multi-layered microporous polycaprolactone (PCL) scaffold is created with interlayer angles set at 45° to replicate the precise structure of native cardiac tissue. Compared with the control group and 90° PCL scaffolds, the 45° PCL scaffolds exhibited superior biocompatibility for cell culture and improved hiPSC-CM maturation in calcium handling.
View Article and Find Full Text PDFRoles of calcium in ameloblasts during tooth development: A scoping review.
J Taibah Univ Med Sci
February 2025
Department of Prosthodontics/Dental Material, Dr. Ziauddin Ahmad Dental College, Aligarh Muslim University, India.
Objectives: Calcium ions (Ca) play crucial role in tooth development, particularly in maintaining enamel density during amelogenesis. Ameloblasts require specific proteins such as amelogenin, ameloblastin, enamelin, kallikrein, and collagen for enamel growth. Recent research has highlighted the importance of calcium and fluoride ions, as well as the TRPM7, STIM, and SOCE pathways, in regulating various stages of enamel formation.
View Article and Find Full Text PDFMolecular Insights Into the Sensory Adaption of the Cave-Dwelling Leech to the Karst Cave Environment.
Ecol Evol
January 2025
Hunan Provincial Key Laboratory of Ecological Conservation and Sustainable Utilization of Wulingshan Resources College of Biology and Environmental Sciences, Jishou University Jishou Hunan China.
Karst caves are a unique environment significantly different from the external environment; adaptation of cave-dwelling animals to the cave environment is often accompanied by shifts in the sensory systems. Aquatic and terrestrial leeches have been found in the karst caves. In this study, we conducted a transcriptome analysis on the cave-dwelling leech .
View Article and Find Full Text PDFPreparation of sandwich-structured VO direct current magnetron sputtering for high-capacity zinc-ion batteries.
Nanoscale
January 2025
College of Science, China Agricultural University, Beijing, 100083, China.
Aqueous zinc-ion batteries are an appealing electrochemical energy storage solution due to their affordability and safety. Significant attention has been focused on vanadium oxide cathode materials for ZIBs, owing to their high specific capacity, unique layered or tunnel structures, and low cost. Compared to traditional methods for preparing and assembling electrode materials, direct current (DC) magnetron sputtering allows direct synthesis and uniform deposition on current collectors, offering advantages such as simplicity, mild reaction conditions, and strong film adhesion.
View Article and Find Full Text PDFA New Mechanism of Supraventricular Tachycardia: Gene Mutation.
Curr Cardiol Rev
January 2025
Department of Cardiology, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Background: Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially in the emergency department, with rapid onset and urgent management. The review highlights the recent genetic predispositions and mechanisms in SVT.
Methods: Through analysis of epidemiology, familial clustering, and gene mutations of the relevant literature，the review elucidates the genetic properties and potential pathophysiology of SVT.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!