AI Article Synopsis
- Alzheimer's disease (AD) involves significant brain cell death and progressive cognitive decline, with neuroinflammation recognized as a key factor in its progression, particularly through the role of microglia cells.
- Recent research indicates that cannabinoids could serve as a preventive treatment for AD, as altered levels of endocannabinoids and their receptors are linked to neurodegenerative conditions.
- The review highlights the potential of cannabinoid receptor (CBR) modulation to protect against neuroinflammation and discusses the development of new drugs targeting these receptors as a promising strategy for managing AD.
Article Abstract
Alzheimer's disease (AD) is characterized by massive neuronal death, brain atrophy, and loss of neurons and synapses, which all lead to a progressive cognitive decline. Neuroinflammation has been recently identified as one of the main causes of AD progression, and microglia cells are considered to have a central role in this process. Growing evidence suggests that cannabinoids may be used as preventive treatment for AD. An altered expression of the endocannabinoids (eCBs) and their receptors (CBRs) is reported in several neurodegenerative disorders, including AD. Moreover, the modulation of CBRs demonstrated neuroprotective effects in reducing aggregated protein deposition, suggesting the therapeutic potential of natural and synthetic CBR ligands in the treatment of neurodegenerative proteinopathies. Here, we review the current knowledge regarding the involvement of CBRs in the modulation of microglia activation phenotypes, highlighting the role of neuroinflammation in the pathogenesis of neurodegenerative diseases, like AD. We also provide an overview of recently developed candidate drugs targeting CBRs that may afford a new innovative strategy for the treatment and management of AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10707618 | PMC |
| http://dx.doi.org/10.3390/jcm12237201 | DOI Listing |
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