AI Article Synopsis
- The liver is crucial for metabolism and detoxification but is at risk of damage from infections, drugs, alcohol, and autoimmune diseases, complicating treatment for patients needing medication.
- Acetaminophen (APAP) is generally safe but can cause liver toxicity in high doses, prompting this study to investigate its hepatotoxic effects and potential natural treatment options using mice.
- The research found that certain natural products showed promise in protecting the liver, indicating they could help mitigate damage and improve liver function by addressing oxidative stress and inflammation, highlighting the need for new treatment strategies for drug-induced liver injury.
Article Abstract
The liver plays a vital role in metabolism, synthesis, and detoxification, but it is susceptible to damage from various factors such as viral infections, drug reactions, excessive alcohol consumption, and autoimmune diseases. This susceptibility is particularly problematic for patients requiring medication, as drug-induced liver injury often leads to underestimation, misdiagnosis, and difficulties in treatment. Acetaminophen (APAP) is a widely used and safe drug in therapeutic doses but can cause liver toxicity when taken in excessive amounts. This study aimed to investigate the hepatotoxicity of APAP and explore potential treatment strategies using a mouse model of APAP-induced liver injury. The study involved the evaluation of various natural products for their therapeutic potential. The findings revealed that natural products demonstrated promising hepatoprotective effects, potentially alleviating liver damage and improving liver function through various mechanisms such as oxidative stress and inflammation, which cause changes in signaling pathways. These results underscore the importance of exploring novel treatment options for drug-induced liver injury, suggesting that further research in this area could lead to the development of effective preventive and therapeutic interventions, ultimately benefiting patients with liver injury caused by medicine.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10708418 | PMC |
| http://dx.doi.org/10.3390/molecules28237901 | DOI Listing |
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