AI Article Synopsis
- N-N atropisomers are gaining attention in research due to their potential applications.
- The article investigates the energy barrier for racemization in atropoisomeric hydrazides using both experimental and computational methods, focusing on electronic and steric influences.
- Findings reveal that the heightened p-orbital character of nitrogen atoms significantly contributes to the energy barrier during the racemization process.
Article Abstract
N-N atropisomers represent a useful class of compounds that has recently received important attention from many research groups. This article presents an in-depth analysis of the energy barrier needed for the racemization process of atropoisomeric hydrazides, combining an experimental and computational approach. The focus is on examining how electronic and steric factors impact the racemization process. The results obtained indicate that the barrier observed during the racemization process mainly arises from an increase in the p-orbital character of the nitrogen atoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10708319 | PMC |
| http://dx.doi.org/10.3390/molecules28237856 | DOI Listing |
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