The scopes and limitations of theoretical methods for estimating various NMR metrics of NHCs are considered on a wide range of model NHCs and their derivatives, using a number of computational approximations. On the whole, the most reliable, from the point of view of predictability and insusceptibility to additional effects, are P/C NMR shifts of NHC-phosphinidene adducts and C CSs of carbenes themselves. The method based on the analysis of Se CS NHC-selenoureas has some limitations since the observed NMR parameters can also be modulated by exchange effects due to their formation with non-classical hydrogen bonds. As for HEP, since the delicate balance of electron distribution between Pd and two carbon centers can nonlinearly affect relativistic spin-orbit effects, the accuracy of the estimation of this metric may still be limited. C CSs of NHC-azolium salts do not seem to be reliable, since the observed values are strongly influenced by the effects of the exchange between different forms with counterions, which are difficult to estimate correctly.
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http://dx.doi.org/10.3390/molecules28237729 | DOI Listing |
Sleep Adv
December 2024
Department of Allergy, Division of Pediatric Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital, Chicago, IL, USA.
Study Objectives: The complete blood count (CBC) is one of the most commonly ordered blood tests with a large range of reference values that does not consider time of day for interpretation. Our objective was to systematically review this topic to report on peak and trough timing of CBC values.
Methods: A systematic search was performed for studies evaluating any component of the CBC with at least three collections over 24 hours.
Front Endocrinol (Lausanne)
December 2024
One Health Research Group, Universidad de las Americas, Quito, Ecuador.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells, with 80-85% originating in the adrenal medulla and 15-20% from extra-adrenal chromaffin tissues (paragangliomas). Approximately 30-40% of PPGLs have a hereditary component, making them one of the most genetically predisposed tumor types. Recent advances in genetic research have classified PPGLs into three molecular clusters: pseudohypoxia-related, kinase-signaling, and -signaling pathway variants.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Neuropathic pain (NP) is an ineffectively treated, debilitating chronic pain disorder that is associated with maladaptive changes in the central nervous system, particularly in the spinal cord. Murine models of NP looking at the mechanisms underlying these changes suggest an important role of microglia, the resident immune cells of the central nervous system, in various stages of disease progression. However, given the number of different NP models and the resource limitations that come with tracking longitudinal changes in NP animals, many studies fail to truly recapitulate the patterns that exist between pain conditions and temporal microglial changes.
View Article and Find Full Text PDFWorld J Gastrointest Surg
December 2024
Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
Background: Previous studies suggest that appendectomy has a protective effect against ulcerative colitis (UC); however, relatively few studies focusing on this topic have been reported in China.
Aim: To explore the correlation between appendectomy and the onset of UC.
Methods: A total of 313 patients with newly diagnosed UC and 313 healthy individuals were selected for this study.
BMC Health Serv Res
December 2024
Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, PB 4 St. Olavs Plass, N - 0130, Oslo, Norway.
Background: As the world's most populous country, India faces a growing challenge in addressing dementia, in which advancing age remains the strongest risk factor. Approximately 8.8 million Indians over the age of 60 are currently affected by this condition.
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