AI Article Synopsis
- This survey explores the complex role of palmitoylation in various types of cell death related to cancer, particularly its connections to tumor development through the Asp-His-His-Cys (DHHC) family of proteins.
- It highlights advancements in detection methods, showing a shift from basic techniques to more sophisticated tools that enhance our understanding of palmitoylation.
- The review also discusses promising therapeutic agents like Ezurpimtrostat and dimeric chloroquine, pointing to their potential in targeting palmitoylation for innovative cancer treatments and improving our understanding of cancer biology.
Article Abstract
In this comprehensive survey, we delve into the multifaceted role of palmitoylation across various cell death modalities in the oncological context, from its intricate correlations with tumorigenesis, steered by the Asp-His-His-Cys tetrapeptide motif (DHHC) family, to the counter-process of depalmitoylation mediated by enzymes like Palmitoyl protein thioesterase-1 (PPT1). Innovations in detection methodologies have paralleled our growing understanding, transitioning from rudimentary techniques to sophisticated modern methods. Central to our discourse are agents like Ezurpimtrostat (GNS561) and dimeric chloroquine (DC661), promising heralds in palmitoylation-targeted cancer therapy. Collectively, this review accentuates palmitoylation's transformative potential in oncology, foreshadowing groundbreaking therapeutic strategies and deepening our molecular comprehension of cancer dynamics.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705081 | PMC |
| http://dx.doi.org/10.3390/cancers15235503 | DOI Listing |
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