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Synthetic Biology to Engineer Bacteriophage Genomes. | LitMetric

Synthetic Biology to Engineer Bacteriophage Genomes.

Methods Mol Biol

CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal.

Published: December 2023

AI Article Synopsis

  • - Recent advancements in synthetic biology have led to new techniques for creating specialized bacteriophages with enhanced functions.
  • - Engineered bacteriophages can be utilized for various applications, such as controlling and detecting pathogens, targeted drug delivery, and material assembly.
  • - The chapter discusses two successful strategies for genetically engineering bacteriophage genomes: bacteriophage recombineering of electroporated DNA (BRED) and a yeast-based phage-engineering platform.

Article Abstract

Recent advances in the synthetic biology field have enabled the development of new molecular biology techniques used to build specialized bacteriophages with new functionalities. Bacteriophages have been engineered toward a wide range of applications, including pathogen control and detection, targeted drug delivery, or even assembly of new materials.In this chapter, two strategies that have been successfully used to genetically engineer bacteriophage genomes will be addressed: the bacteriophage recombineering of electroporated DNA (BRED) and the yeast-based phage-engineering platform.

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Source
http://dx.doi.org/10.1007/978-1-0716-3523-0_17DOI Listing

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