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Switch from eculizumab to satralizumab in aquaporin 4 immunoglobulin G-seropositive neuromyelitis optica spectrum disorder: a case series report.
Front Immunol
January 2025
Genentech, Inc., South San Francisco, CA, United States.
Objectives: This case series describes adults with aquaporin 4 immunoglobulin G-seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) who switched treatment from eculizumab to satralizumab.
Methods: Case information for patients with AQP4-IgG+ NMOSD who received satralizumab for ≥6 months was obtained from US healthcare providers from April 2022 to January 2024. Patient characteristics, examination findings, diagnostic test results, treatment response, and adverse events were recorded.
Empowering wastewater treatment with step scheme heterojunction ternary nanocomposites for photocatalytic degradation of nitrophenol.
Sci Rep
January 2025
Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh, 11541, Saudi Arabia.
The ongoing challenge of water pollution necessitates innovative approaches to remove organic contaminants from wastewater. In this work, new two-dimensional S-scheme heterojunction photocatalysts BiO/CdS and MoS/BiO/CdS that are intended for the effective photocatalytic destruction of 4-nitrophenol, a dangerous organic pollutant, are synthesized and characterized. Utilizing a solvothermal method, successfully generated these ternary nanocomposites, which were characterized through various techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), high resolution transmission electronmicroscopy (HRTEM), Brunauer-Emmett-Telle (BET) and diffuse reflectance spectroscopy (DRS).
View Article and Find Full Text PDFLong-Term Family Needs After a Traumatic Brain Injury: A VA TBI Model Systems Study.
J Head Trauma Rehabil
January 2025
Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota (Tsen); Department of Physical Medicine and Rehabilitation, Rehabilitation & Extended Care, Minneapolis VA Health Care System, Minneapolis, Minnesota (Dr Finn); Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota (Dr Finn); Department of Research Methodology and Biostatistics, Morsani College of Medicine, University of South Florida, Tampa, Florida (Mrs Klocksieben); Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts (O'Neil-Pirozzi); Department of Communication Sciences & Disorders, Northeastern University, Boston, Massachusetts (Dr O'Neil-Pirozzi); H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas (Dr Sander); Brain Injury Research Center, TIRR Memorial Hermann, Houston, Texas (Dr Sander); Department of Research, Craig Hospital, Englewood, Colorado (Drs Agtarap and Finn); Departments of Ophthalmology & Visual Sciences and Physical Medicine & Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama (Dr Dreer); Research Service, James A. Haley Veterans Hospital, Tampa, Florida (Dr Cotner); Research Service, Traumatic Brain Injury Center of Excellence at James A. Haley Veterans Hospital, Tampa, Florida (Drs Cotner and Nakase-Richardson); Research Department, Central Virginia Veterans Affairs Health Care System, Richmond, Virginia (Mss Vargas, and Dini, and Dr Perrin); Department of Psychology, Virginia Commonwealth University, Richmond, Virginia (Ms Vargas); Department of Psychology, University of Virginia, Charlottesville, Virginia (Ms Dini and Dr Perrin); Mental Health, School of Data Science, University of Virginia, Charlottesville, Virginia (Dr Perrin); Mental Health and Behavioral Services, James A. Haley Veterans Hospital, Tampa, Florida (Drs Finn and Nakase-Richardson); and Department of Internal Medicine, Pulmonary and Sleep Medicine Division, University of South Florida, Tampa, Florida (Dr Nakase-Richardson).
Objective: To describe the self-reported needs of family caregivers of service members and veterans (SMVs) with traumatic brain injury (TBI) at 10 to 15 years post-injury and to identify unique predictors of unmet family needs.
Setting: Five Department of Veterans Affairs Polytrauma Rehabilitation Centers.
Participants: A total of 209 family caregivers of SMVs with TBI from the VA TBI Model Systems national database who completed a 10- or 15-year follow-up assessment.
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow.
Immunity
January 2025
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Electronic address:
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a proinflammatory state in the host. Here, we investigated innate immune responses following increased gut permeability upon administration of dextran sulfate sodium (DSS) in mice. We found that Enterococcus faecalis translocated to the bone marrow following DSS treatment and induced trained immunity (TI) hallmarks in bone-marrow-derived mouse macrophages and human monocytes.
View Article and Find Full Text PDFAssociations Between Sugar-Sweetened Beverage Taxes and Weight Outcomes Among US Adolescents.
J Public Health Manag Pract
January 2025
Author Affiliations: Department of Economics, Boston College, Chestnut Hill, Massachusetts (Drs Cui, Baum, and Hawkins); Boston College, School of Social Work, Chestnut Hill, Massachusetts (Drs Baum and Hawkins); and Centre of Excellence for Science and Innovation Studies, Stockholm, Norway (Dr Baum).
Given the recent implementation and preemption of sugar-sweetened beverage taxes across the United States, we aimed to evaluate the associations between sugar-sweetened beverage (SSB) taxes and adolescent weight-related outcomes using data on 364,540 adolescents drawn from 1999 to 2021 district Youth Risk Behavior Surveys. We used difference-in-differences models to assess the associations and the potential mediating roles of SSBs, milk, and 100% fruit juice consumption. We found that a one cent per ounce increase in SSB taxes was associated with a 0.
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