AI Article Synopsis
- - The study aimed to evaluate how effective seven different Covid-19 vaccines were in preventing serious health issues during the Omicron wave in Mexico between January and March 2022.
- - An analysis of data from private sector workers who tested positive for SARS-CoV-2 showed that vaccinated individuals had significantly lower hospitalization and death rates compared to those who were unvaccinated.
- - Specific vaccines like Pfizer BioNTech and Moderna demonstrated particularly strong effectiveness, with adjusted risk ratios indicating much lower chances of hospitalization and death for vaccinated individuals.
Article Abstract
Objective: To assess the effectiveness of seven Covid-19 vaccines in preventing disease progression (DP) using data from national private sector workers during the Omicron wave in Mexico from January 2 to March 5, 2022.
Materials And Methods: This study employed an administrative retrospective cohort design, analyzing DP (hospitalization or death due to respiratory disease) among workers who filed a respiratory short-term disability claim and tested positive for SARS-CoV-2. Risk ratios (RRadj) were estimated using Poisson regression models adjusted for various factors.
Results: Vaccinated individuals had a lower risk of hospitalization and death compared with unvaccinated individuals. The overall RRadj for hospitalization and death were 0.36 (95%CI 0.32, 0.41) and 0.24 (0.17, 0.33), respectively. When evaluating vaccines individually, the RRadj for hospitalization were as follows Pfizer BioNTech 0.27 (95%CI 0.22, 0.33), Moderna 0.29 (95%CI 0.15, 0.57), Sinovac 0.32 (95%CI 0.25, 0.41), AstraZeneca 0.39 (95%CI 0.34, 0.46), Sputnik 0.39 (95%CI 0.28, 0.53), CanSino 0.41 (95%CI 0.24, 0.7), and Janssen 0.53 (95%CI 0.39, 0.72). The RRadj for death were as follows: Pfizer BioNTech 0.12 (95%CI 0.07, 0.19), Sputnik 0.15 (95%CI 0.06, 0.38), Sinovac 0.29 (95%CI 0.16, 0.53), AstraZeneca 0.30 (95%CI 0.20, 0.44), CanSino 0.38 (95%CI 0.1, 1.4), and Janssen 0.50 (95%CI 0.26, 0.97).
Conclusion: Covid-19 vaccines significantly reduced the risk of severe disease during the Omicron wave in Mexico.
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| http://dx.doi.org/10.21149/15125 | DOI Listing |
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