AI Article Synopsis
- High-intensity focused ultrasound (HIFU) is a promising treatment option for women with adenomyosis who want to preserve their uterus and possibly their fertility.
- A systematic review and meta-analysis of 10 studies involving 557 patients revealed an overall pregnancy rate of 53.4% and a live birth rate of 35.2%, but these results showed considerable variability across studies.
- Despite the potential benefits of HIFU for improving fertility in these patients, current evidence is weak, indicating a need for more rigorous comparative studies, particularly randomized clinical trials, to validate these findings.
Article Abstract
High-intensity focused ultrasound (HIFU) has emerged as a promising uterus-sparing and possibly fertility-sparing treatment modality for women with adenomyosis, especially those who desire to conceive. We conducted this systematic review and performed a meta-analysis on clinical studies aimed to improve reproduction in women with adenomyosis. After extensive search of PubMed and CNKI, we identified 10 studies published in English and Chinese involving a total of 557 patients with adenomyosis who desired to conceive after HIFU treatment. We found a pooled estimate of pregnancy rate of 53.4% and of the live birth rate of 35.2%, and there was a substantial heterogeneity among these studies. While there is a potential for HIFU treatment to improve fertility for patients with adenomyosis who desired to conceive, such evidence is very weak as of now. Comparative studies with much higher methodological rigor, preferably randomized clinical trials, are badly needed to further illuminate this issue.
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| http://dx.doi.org/10.1016/j.bpobgyn.2023.102433 | DOI Listing |
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