AI Article Synopsis
- The study explores the possibility of predicting infant age using sensory-evoked cortical potentials to identify abnormal neurodevelopment.
- Infants aged 28-40 weeks post-menstrual age were tested with visual and tactile stimuli, and a machine learning model was used to analyze their neurodynamic responses.
- Results showed that the model accurately predicted infant age, linking deviations in brain age to significant differences in nervous system maturation, which could help in assessing long-term neurodevelopmental outcomes.
Article Abstract
Objective: We investigated whether sensory-evoked cortical potentials could be used to estimate the age of an infant. Such a model could be used to identify infants who deviate from normal neurodevelopment.
Methods: Infants aged between 28- and 40-weeks post-menstrual age (PMA) (166 recording sessions in 96 infants) received trains of visual and tactile stimuli. Neurodynamic response functions for each stimulus were derived using principal component analysis and a machine learning model trained and validated to predict infant age.
Results: PMA could be predicted accurately from the magnitude of the evoked responses (training set mean absolute error and 95% confidence intervals: 1.41 [1.14; 1.74] weeks,p = 0.0001; test set mean absolute error: 1.55 [1.21; 1.95] weeks,p = 0.0002). Moreover, we show that their predicted age (their brain age) is correlated with a measure known to relate to maturity of the nervous system and is linked to long-term neurodevelopment.
Conclusions: Sensory-evoked potentials are predictive of age in premature infants and brain age deviations are related to biologically and clinically meaningful individual differences in nervous system maturation.
Significance: This model could be used to detect abnormal development of infants' response to sensory stimuli in their environment and may be predictive of neurodevelopmental outcome.
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| http://dx.doi.org/10.1016/j.clinph.2023.11.007 | DOI Listing |
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