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siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival.
Curr Gene Ther
January 2025
Department of Pharmacology, Faculty of Medicine, The University of Jordan, Queen Rania Al-Abdullah Street, Amman 11942, Jordan.
Introduction: Liposomes are versatile delivery systems for encapsulating small interfering RNAs (siRNAs) because they enhance cellular uptake and gene silencing. This study compares the new liposome formula to commercial lipofectamine in delivering siRNAs targeting hepatic carcinoma genes, focusing on HNF4-α and PFKFB4.
Methods: Flow cytometry and confocal microscopy revealed efficient internalization of PE-Rhod- B labeled lipoplexes in HepG2 cells, while cytotoxicity assays demonstrated significant reductions in cell viability, particularly with siHNF4-α and siPFKFB4.
Trip route optimization based on bus transit using genetic algorithm with different crossover techniques: a case study in Konya/Türkiye.
Sci Rep
January 2025
Faculty of Medicine, Department of Medical Education and Informatics, Karamanoğlu Mehmetbey University, Karaman, 70200, Türkiye.
With the importance of time and cost in today's world, it is essential to solve problems in the best way possible. Optimization is a process used to achieve this goal and is applied in several areas, one of which is route planning. Route optimization minimizes the use of resources such as fuel, distance, and time.
View Article and Find Full Text PDFIn the current cybersecurity landscape, Distributed Denial of Service (DDoS) attacks have become a prevalent form of cybercrime. These attacks are relatively easy to execute but can cause significant disruption and damage to targeted systems and networks. Generally, attackers perform it to make reprisal but sometimes this issue can be authentic also.
View Article and Find Full Text PDFCON: It's time for new strategies to optimize liver transplant immunosuppression.
Liver Transpl
January 2025
Department of Medicine, Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
Science tells us that portable air filters reduce infection risk. It's time for public health authorities to make this clear.
J Infect Public Health
January 2025
Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, Ontario M5T 3M7, Canada; Department of Civil & Mineral Engineering, 35 St. George St, Toronto, Ontario M5S 1A4, Canada.
Throughout the COVID-19 pandemic, Canadian public health advisors and politicians have shared mixed messages about the utility of portable air filters (PAFs) for mitigating the transmission of airborne infectious diseases. Some public health advisors and decision-makers have also suggested that PAFs are cumbersome or require expert advice. We take this opportunity to review evidence and address myths about PAFs.
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