Background: Asbestos is considered one of the major global work-related carcinogens. Some studies suggest a potential causal relationship between asbestos exposure and colorectal cancer (CRC). However, the role of asbestos in CRC carcinogenesis is still controversial.
Methods: 35 claims of occupational CRC among asbestos-exposed workers were reviewed. All claims were rejected by the Italian National Institute for Insurance against Accidents (INAIL) due to the "lack of scientific evidence in the causality" between asbestos exposure and CRC; causality was finally assessed in civil trials. All cases were categorized by age, gender, industry type, task, exposure and latency periods, anatomical location, and histopathological characteristics of CRC and concomitant respiratory diseases.
Results: Most workers were males aged 60 years or more and employed in occupational activities with extensive use of asbestos for over 20 years. In 31 out of 35 cases, CRC was diagnosed over 39 years after employment. Right-sided colic adenocarcinoma was diagnosed in nine cases; rectum was involved in eight cases. Respiratory comorbidities were observed in 22 workers.
Conclusions: Our study provides some interesting points in the assessment of the causal relationship between asbestos exposure and CRC.
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http://dx.doi.org/10.3390/healthcare11233077 | DOI Listing |
Med Lav
December 2024
Department of Health Sciences; Course of Research Doctorate in Public Health Sciences, University of Milan, Milan, Italy/Occupational Health Unit, Santi Paolo e Carlo Hospital, Milan, Italy.
The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area.
View Article and Find Full Text PDFNew Solut
December 2024
Early, Lucarelli, Sweeney & Meisenkothen, LLC, New Haven, CT, USA.
Over a century ago, Connecticut industry began using chrysotile asbestos. Chrysotile found a home in several factories that used it exclusively or predominantly. The occurrence of mesothelioma in 4 of those factories is the subject of this paper-2 have been reported previously and are updated here with new information; one was the subject of a prior internal corporate study that was never published; one is reported here for the first time.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Background: Mesothelioma of the tunica vaginalis testis (MTVT) is an extremely rare and aggressive cancer. The diagnosis and management of MTVT is complex, and no standard treatment protocol is available.
Methods: We conducted a systematic literature review from 1 January 1982 to 14 March 2024 using PubMed to collect all the available case reports and case series.
Epidemiol Prev
December 2024
Dipartimento di Medicina, Epidemiologia, Igiene del lavoro e ambientale, Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, Roma.
Objectives: to provide an overview of the geographical distribution of mesothelioma and asbestosis deaths in the Campania Region (Southern Italy) occurred from 2005 to 2018 and to identify areas at higher risk.
Design: for each municipality, Standardized Mortality Ratios (SMRs) for mesothelioma and asbestosis have been estimated from the mortality data provided by the Italian National Institute of Statistics (Istat). Deaths for which mesothelioma and asbestosis were identified as the underlying causes, according to the classification system ICD-10 codes (C45 and J61, respectively), were included.
Toxicology
December 2024
Department Earth, Environment and Life Sciences, University of Genova, Genova 16132, Italy; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), Pisa 56122, Italy.
Asbestos minerals have been widely exploited due to their physical-chemical properties, and chrysotile asbestos has accounted for about 95% of all asbestos commercially employed worldwide. The exposure to chrysotile, classified like other five amphibole asbestos species as carcinogenic to humans, represents a serious occupational and environmental hazard. Nevertheless, this mineral is still largely employed in about 65% of the countries worldwide, which still allow its "safe use".
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