is a symbiont with a strong malaria transmission-blocking phenotype in . It spreads in mosquito populations through mother-to-offspring and sexual transmission. The ability of to block transmission, together with its ability to spread within populations and its avirulence to the host, makes it a very attractive candidate for developing a key strategy to stop malaria transmissions. Here, we report tissue tropism and localization patterns of , which are relevant to its transmission. We find that accumulates in tissues, linked to its sexual and vertical transmission. Its prevalence and intensity in the tissues over the mosquito life cycle suggest adaptation to maximize transmission and avirulence in . These findings provide the foundation for understanding the factors that may affect transmission efficiency. This will contribute to the development of strategies to maximize transmission to establish and sustain a high prevalence of the symbiont in mosquito populations for malaria transmission blocking.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790688 | PMC |
| http://dx.doi.org/10.1128/mbio.02192-23 | DOI Listing |
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