Background: Blinatumomab improved survival outcomes in B-cell acute lymphoblastic leukemia (B-ALL) patients with measurable residual disease (MRD) <10 . However, data on blinatumomab clearing MRD with high sensitivity of 10 remain scarce. This study evaluates the effectiveness of blinatumomab in eradicating extremely low level (up to <10 ) of MRD, as detected by next-generation sequencing (NGS), in children with B-ALL.
Methods: Patients (n = 19) whose MRD was undetectable by multiparameter flow cytometry (MFC) (sensitivity of 10 ) but detectable by NGS after chemotherapy and followed by blinatumomab consolidation were included retrospectively.
Results: After one course of blinatumomab, 13/19 patients (68%) successfully achieved NGS-MRD clearance (undetectable). With a median follow-up of 13.3 months, three of patients who were NGS-MRD positive relapsed within 1.8 months, while another three remained complete remission.
Conclusions: Our study was the first to demonstrate that blinatumomab could further eradicate MRD after patients achieve MFC-MRD undetectable in B-ALL patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757083 | PMC |
| http://dx.doi.org/10.1002/cam4.6771 | DOI Listing |
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