Inflammatory Profile in Left Ventricular Apical Thrombus.

Objective: To investigate the relationship between systemic immune inflammation index (SII), C-reactive protein/albumin ratio (CAR), lymphocyte/CRP ratio (LCR), and apical thrombus development.

Study Design: Observational, cross-sectional study. Place and Duration of the Study: Bursa City Hospital, Turkey, from 1st January to 31st March 2023.

Methodology: Twenty-two patients with a clinical presentation of acute anterior myocardial infarction and diagnosed with LVAT during follow-up were included. Sixty-eight patients with acute anterior myocardial infarction (AMI) were selected as the control group (comparison). Clinical and demographic characteristics, laboratory data, echocardiographic findings, coronary angiography, and percutaneous coronary intervention data were recorded. SII was calculated by the formula Neutrophil (N) × Platelet (P) / Lymphocyte (L). CAR and LCR values were also determined.

Results: While there was no significant difference between the two groups in terms of SII, CAR was significantly higher and LCR was significantly lower in the apical thrombus group. The cut-off value for CAR was 0.165 (sensitivity=63.64%, specificity=74.60%, AUC=0.718; p <0.05). For LCR, the AUC value of 0.382 and below was found to indicate the presence of apical thrombus with a probability of 69.8% (sensitivity=68.18%, specificity=67.16%, p= 0.002).

Conclusion: No significant relationship was found between SII and apical thrombus in the detection of LVAT, whereas high CAR and low LCR were associated with the presence of apical thrombus.

Key Words: Left ventricular apical thrombus, Apical aneurysm, C-reactive protein/albumin ratio, Lymphocyte/C-reactive protein ratio, Systemic immune inflammation index.