AI Article Synopsis
- Breast cancer has various aggressive subtypes, with triple-negative breast cancer (TNBC) being notably impactful, contributing to 25% of cases.
- miRNAs, which can regulate a significant portion of human genes, show promise as minimally invasive diagnostic markers for TNBC when their expression is analyzed in liquid biopsies.
- The study found that specific miRNAs, particularly miRNA-155 and miRNA-21, are significantly upregulated, while miRNA-205 is downregulated in TNBC patients, providing a combined diagnostic accuracy of over 94% across multiple cohorts.
Article Abstract
Breast cancer is a highly aggressive type of cancer and has several subtypes, including triple-negative breast cancer (TNBC), which accounts for 25% of morbidity related to breast cancer. miRNAs are small non-coding RNA molecules that regulate 60% of human genes. Dysregulated expression of miRNA in liquid biopsy of TNBC patients has the potential as a minimally invasive diagnostic biomarker. The Association of miRNA with TNBC was evaluated using in-silico analysis. Highly enriched miRNAs were selected for functional analysis to evaluate the role of miRNA in the progression of TNBC. The qRT-PCR-based expression analysis of miRNA was performed in 190 serum samples (139 TNBC and 51 healthy). Revealed the elevated expression of miRNA-155 and miRNA-21 in TNBC compared to control samples (P < 0.0001), while miRNA-205 was significantly downregulated in TNBC (P < 0.0001). The combined diagnostic value of the miRNA-205, miRNA-155 and miRNA-21 in cohort-I, cohort-II, and cohort-III was AUC of 96.1% (P < 0.0001), 94.9% (P < 0.0001), and 97.1% (P < 0.0001), respectively. Our study revealed that dysregulated expression of miRNA could be used as an independent indicator for discriminating TNBC from healthy patients. In addition, the combined predictive value of miRNA-205 + miRNA - 155 + miRNA-21 has higher AUC, sensitivity, and specificity in the diagnosis of TNBC in all three cohorts.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10703933 | PMC |
| http://dx.doi.org/10.1038/s41598-023-48896-7 | DOI Listing |
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