AI Article Synopsis
- Education is crucial for economic stability and mental health, yet mental disorders can negatively impact educational achievement, indicating complex genetic relationships.* -
- The study analyzed how polygenic risk scores for six mental disorders affect detailed educational outcomes in a large sample of nearly 80,000 individuals, focusing on school performance in language and mathematics.* -
- Results showed that high genetic risk for ADHD correlated with lower grades, while higher genetic risks for anorexia and bipolar disorder linked to better grades, highlighting the varied genetic influences on academic performance.*
Article Abstract
Background: Education is essential for socioeconomic security and long-term mental health; however, mental disorders are often detrimental to the educational trajectory. Genetic correlations between mental disorders and educational attainment do not always align with corresponding phenotypic associations, implying heterogeneity in the genetic overlap.
Methods: We unraveled this heterogeneity by investigating associations between polygenic risk scores for 6 mental disorders and fine-grained school outcomes: school grades in language and mathematics in ninth grade and high school, as well as educational attainment by age 25, using nationwide-representative data from established cohorts (N = 79,489).
Results: High polygenic liability of attention-deficit/hyperactivity disorder was associated with lower grades in language and mathematics, whereas high polygenic risk of anorexia nervosa or bipolar disorder was associated with higher grades in language and mathematics. Associations between polygenic risk and school grades were mixed for schizophrenia and major depressive disorder and neutral for autism spectrum disorder.
Conclusions: Polygenic risk scores for mental disorders are differentially associated with language and mathematics school grades.
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| http://dx.doi.org/10.1016/j.biopsych.2023.11.020 | DOI Listing |
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