Sex Differences in Cardiac Transplantation.

Curr Atheroscler Rep

Center for Advanced Cardiac Care, Division of Cardiology, Columbia University Irving Medical Center, 622 West 168th Street, PH 12-1284, New York, NY, 10032, USA.

Published: December 2023

AI Article Synopsis

  • * Various factors contribute to the underrepresentation of women in HT, including barriers to access, implicit bias, and increased waitlist mortality, especially at higher priority levels.
  • * The study calls for further research on sex-specific issues related to noninvasive monitoring, kidney outcomes post-transplant, and patient experiences, emphasizing the need for equal referral patterns to improve outcomes for women in heart transplantation.

Article Abstract

Purpose Of Review: The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT).

Recent Findings: Women have steadily comprised approximately 25% of waitlist candidates and HT recipients. This disparity is likely multifactorial with possible explanations including barriers in referral to advanced heart failure providers, implicit bias, and concerns surrounding sensitization. Women continue to experience higher waitlist mortality at the highest priority tiers. After HT, there are differences in post-transplant complications and outcomes. Future areas of study should include sex differences in noninvasive surveillance, renal outcomes after transplantation, and patient-reported outcomes. There are important sex-specific considerations that impact candidate selection, donor matching, waitlist and post-transplant outcomes. Concerted efforts are needed to improve referral patterns to ensure transplantation is allocated equally.

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Source
http://dx.doi.org/10.1007/s11883-023-01169-0DOI Listing

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