The postnatal maturation of the epithelium and tubule wall of efferent tubules in the rat was investigated by light and transmission electron microscopy, from birth to 50 days of age, when sperms were released from the seminiferous tubules and appeared in the genital duct. At the end of the first week of life, an endocytotic apparatus is differentiated in the epithelial cells. During the third week of life, efferent tubules developed specializations for the transport of sperms and fluids, namely the appearance of ciliated elements interspersed among the principal cells of the epithelium, and differentiation of myoid elements in the tubule wall. The appearance of specializations related to endocytosis and fluid transport across the epithelium preceded the canalization of the seminiferous cords which, in fact, is reported to appear at the end of the second week of life in the rat, along with the initial secretion of testicular fluid. This suggested that the maturation of efferent tubules is not triggered by the passage of testicular fluid, as surmised for the postnatal differentiation of caput epididymis. The postnatal maturation of efferent tubules was almost complete 35 days after birth. The appearance of sperms in the genital duct of 50-day-old animals was not associated with any remarkable structural change.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.
Diabetes
January 2025
Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC Canada H2X 0A9.
The role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion of angiotensinogen (Agt; RT-Agt-/-) in both Akita and streptozotocin (STZ)-induced mouse model of diabetes. Both Akita RT-Agt-/- and STZ-RT-Agt-/- mice exhibited significant attenuation of glomerular hyperfiltration, urinary albumin/creatinine ratio, glomerulomegaly and tubular injury.
View Article and Find Full Text PDFThe ductal network in the human testis and epididymis: What belongs to which?
Clin Anat
November 2024
Klinik für Urologie, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany.
Article Synopsis
- The testes and epididymis have a network of tubules responsible for sperm generation, maturation, nourishment, and transport, including the efferent ductules connecting the rete testis to the epididymis.
- There is a debate over whether the efferent ductules belong to the testicles or the epididymis, but clinical evidence supports their classification with the epididymis.
- Correctly identifying components of the epididymis is crucial for assessing testicular cancers, as infiltration by tumors can affect prognosis.
Mesonephric tubules expressing estrogen and androgen receptors remain in the rete ovarii of adult mice.
Cell Tissue Res
November 2024
Department of Anatomy, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
The rete ovarii and epoophoron in females are homologous structures of the rete testis and efferent/epididymal duct in males and are derived from the developing rete cells and mesonephric tubules, respectively. Sex steroid hormones play a critical role in reproductive function for both sexes, and we recently reported expression patterns of sex steroid receptors in developing male reproductive tracts. However, their expression patterns in females remain unclear.
View Article and Find Full Text PDFResponse of the nephron arterial network and its interactions to acute hypertension: a simulation.
Function (Oxf)
November 2024
University of Copenhagen, Department of Biomedical Sciences, Panum Institute Copenhagen, Denmark.
We simulated the dynamics of a group of 10 nephrons supplied from an arterial network and subjected to acute increases in blood pressure. Arterial lengths and topology were based on measurements of a vascular cast. The model builds on a previous version exercised at a single blood pressure with 2 additional features: pressure diuresis and the effect of blood pressure on efferent arteriolar vascular resistance.
View Article and Find Full Text PDFGlomerular pressure and tubular oxygen supply: a critical dual target for renal protection.
Hypertens Res
December 2024
Division of Nephrology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Article Synopsis
- The main goal in treating chronic kidney disease (CKD) is to maintain kidney function and prevent it from worsening to end-stage renal disease.
- Glomerular hypertension and low oxygen supply to kidney tubules are key factors that contribute to CKD progression, complicating treatment due to the kidney's unique blood flow dynamics.
- Promising treatment options include sodium-glucose cotransporter 2 inhibitors and angiotensin receptor-neprilysin inhibitors, as they can help regulate the blood flow and pressure in the kidneys, potentially protecting renal function.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!