Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.

Adv Sci (Weinh)

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China.

Published: February 2024

AI Article Synopsis

  • * Within 48 hours, the transplanted tissue develops its own blood supply and forms thyroid follicles similar to a natural gland, integrating well with surrounding splenic tissue.
  • * This method not only successfully restores hormone regulation but also performs better than traditional levothyroxine therapy, offering new possibilities for treating thyroid disorders.

Article Abstract

Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological stimuli, outperforming the established method of oral levothyroxine therapy in maintaining systemic homeostasis. The study demonstrates the full restoration of thyroid functions post-thyroidectomy by intrasplenic TG regeneration, providing fresh insights for designing novel therapies for thyroid-related disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853707PMC
http://dx.doi.org/10.1002/advs.202305913DOI Listing

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