AI Article Synopsis
- Sulfondiimines are an underexplored but interesting pharmacophore in drug discovery, similar in structure to sulfones and sulfoximines.
- The study introduces a simple and mild photocatalytic method for anti-Markovnikov hydroamination of styrenes, enabling the creation of -alkylated sulfondiimines with various alkyl groups.
- This method was crucial in synthesizing a sulfondiimine-related analogue of the well-known drug Vioxx.
Article Abstract
Sulfondiimines, which are isoelectronic with sulfones and sulfoximines, represent a neglected yet intriguing pharmacophore in the discovery program. Herein, we present a facile and mild photocatalytic anti-Markovnikov hydroamination of styrenes for the construction of -alkylated sulfondiimines with primary, secondary, and tertiary alkyl substituents. A sulfondiimine-derived analogue of the marketed drug Vioxx was synthesized using this method as the key step.
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| http://dx.doi.org/10.1021/acs.orglett.3c03608 | DOI Listing |
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