AI Article Synopsis
- The study investigated the cardioprotective effects of Sanwei sandalwood decoction against Adriamycin-induced Chronic Heart Failure using network pharmacology and molecular docking methods.
- Results showed that the decoction improved heart function in rats, indicated by enhanced ejection fraction and reduced serum markers related to heart damage.
- It also found that treatment lowered the expression of aquaporins (Aquaporin-1, 4, and 7), suggesting their significant role in heart cell health and response to oxidative stress during chronic heart failure.
Article Abstract
This study employed network pharmacology, molecular docking technology, and modern pharmacological research methods to explore the pre-protective effect and underlying mechanism, Sanwei sandalwood decoction, against Adriamycin-induced Chronic Heart Failure, with a particular focus on the involvement of aquaporins. Additionally, the study highlighted aquaporins as a significant factor, affecting processes such as cell proliferation and response to reactive oxygen species. The results of experiments demonstrated that the administration of Sanwei sandalwood decoction in rats with chronic heart failure led to an enhancement in the ejection fraction and improved heart ejection function. Additionally, the decoction significantly reduced the serum levels of Creatine Kinase, Creatine Kinase-MB, and N-terminal pro-B-type natriuretic peptide. Furthermore, the relative expression of Aquarporin-1, 4, and 7mRNAs and proteins in the hearts of rats with chronic heart failure was down-regulated upon treatment. Overall, Sanwei sandalwood decoction can have an effective cardioprotective effect in preventing Adriamycin-induced Chronic Heart Failure in rats.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696208 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e22718 | DOI Listing |
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