AI Article Synopsis
- Shrunken pore syndrome (SPS) in children is determined by specific eGFR ratios and is linked to higher cardiovascular risk, though prior studies haven't shown this connection to increased morbidity and mortality.
- The study examined 307 pediatric patients at renal risk, using various formulas to assess SPS prevalence and its correlation with cardiovascular health.
- Findings indicated that SPS prevalence varies significantly based on the methods used; children with SPS had higher levels of C-reactive protein and phosphate, along with smaller body size, signaling potential long-term cardiovascular issues that warrant further investigation.
Article Abstract
Background: Shrunken pore syndrome (SPS) is defined as cystatin C-based-eGFR (eGFRcys)/creatinine-based-eGFR (eGFRcreat) <0.6 or 0.7 and is associated with an increased cardiovascular risk. SPS has been described in children, but no link to increased morbi-mortality was demonstrated.
Objectives: Study the prevalence of SPS in a pediatric population using several glomerular filtration rate (GFR) estimating formulas and measured GFR and evaluate the potential link with cardiovascular risk.
Methods: In 307 renal risk pediatric patients, we studied prevalence of SPS either with CKiDU25creat and cyst or with FAScreat and cyst and EKFCcreat. The characteristics of patients with SPS (defined with Full-age spectrum equation (FAS) and/or European Kidney Function Consortium equation (EKFC)) were compared.
Results And Conclusion: The prevalence of SPS varies widely depending on the threshold and the formulas used. Higher C-reactive protein (CRP) and phosphate levels and smaller size are observed in children with SPS defined with FAS and/or EKFC and might be associated with long-term increased cardiovascular risk. Further studies in wider general pediatric populations are warranted.
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| http://dx.doi.org/10.1111/joim.13749 | DOI Listing |
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