AI Article Synopsis
- A 29-year-old woman experienced painful swelling and nodules on her legs after taking minocycline for acne for 3 years.
- Biochemical tests revealed liver issues and positive antibodies indicative of an autoimmune response, leading to a skin biopsy that confirmed nodular vasculitis.
- After stopping minocycline, her symptoms and liver function improved within 3 months, prompting caution about long-term minocycline use due to its potential to cause nodular vasculitis.
Article Abstract
A 29-year-old Caucasian woman presented with a 3-month history of bilateral lower limb swelling with painful erythematous nodules on shins without ulceration. She had been taking minocycline for acne vulgaris for 3 years. Biochemical investigations showed deranged liver function test with positive ANA and mixed antinuclear factor (ANF) pattern. A skin biopsy was in keeping with a diagnosis of nodular vasculitis. Her skin lesions and liver function test improved within 3 months of stopping the minocycline treatment. This case report raises the awareness that minocycline could be a potential cause of nodular vasculitis, patients on minocycline should be closely monitored and minocycline should ideally not be prescribed for more than 12 weeks, given the possible adverse effects.
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| http://dx.doi.org/10.1111/ajd.14195 | DOI Listing |
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