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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836900 | PMC |
| http://dx.doi.org/10.1097/CM9.0000000000002931 | DOI Listing |
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Chlamydia genital infection caused by Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. A mouse model has been developed in our laboratory to better understand the effect of cold-induced stress on chlamydia genital infection and immune response. However, the stress mechanism affecting the host response to Chlamydia muridarum genital infection remains unclear.
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Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA; Departments of Medicine, Pathology, Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA; Division of Infectious Disease and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:
Article Synopsis
- * This study investigates how the sympathetic nervous system (SNS) influences the severity of CDI using mouse models and treatments that inhibit SNS activity.
- * The findings show that blocking certain SNS pathways significantly reduces illness severity and mortality in CDI, suggesting that targeting these neural systems could be a potential new treatment approach.
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