Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8 T cells for improved tumor control.
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| http://dx.doi.org/10.1016/j.cmet.2023.11.004 | DOI Listing |
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