Given the current interest in materials containing 1,4-azaborine units, the development of new routes to these structures is important. Carbonyl directed electrophilic borylation using BBr is a facile method for the -borylation of ,-diaryl-amide derivatives. Subsequent addition of EtSiH results in carbonyl reduction and then formation of 1,4-azaborines that can be protected using a Grignard reagent. Overall, borylation-reduction-borylation is a one-pot methodology to access 1,4-azaborines from simple precursors.
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| http://dx.doi.org/10.1021/acs.orglett.3c03731 | DOI Listing |
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