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| http://dx.doi.org/10.22454/FamMed.2023.472634 | DOI Listing |
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T cell induced expression of Coronin-1A facilitates blood-brain barrier transmigration of breast cancer cells.
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Department of Pathology, The Tumor Immuno-Pathology Laboratory, Erasmus University Medical Center, Wytemaweg 80, 3000 DR, Rotterdam, The Netherlands.
In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored how T lymphocytes promote breast cancer cell penetration through the blood brain barrier (BBB). An in vitro BBB model was employed to study the effects of T lymphocytes on BBB trespassing capacity of three different breast carcinoma cell lines.
View Article and Find Full Text PDFAngiotensin 1-7 injected into the rat paraventricular nucleus of hypothalamus increases blood pressure and heart rate via various receptors.
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Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Although angiotensin 1-7 (Ang 1-7) and its role as a part of the "protective" axis of the renin-angiotensin system are well described in the literature, the mechanisms of its angiotensin II-like pressor and tachycardic effects following its acute central administration are not fully understood. It was the aim of the present study to examine which receptors contribute to the aforementioned cardiovascular effects. Ang 1-7 and antagonists for glutamate, GABA, vasopressin, thromboxane A (TP), α-adrenergic, and P2X purinoceptors or modulators of oxidative stress were injected into the paraventricular nucleus of the hypothalamus (PVN) of urethane-anesthetized male Wistar rats.
View Article and Find Full Text PDFImpact of Beta-Alanine, Caffeine, and Their Combination on Intraocular Pressure and Ocular Perfusion Pressure at Rest and After Resistance Training.
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Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
This study aimed to determine the impact of caffeine (200 mg), beta-alanine (3 g), and their combination on intraocular pressure (IOP), ocular perfusion pressure (OPP), and mean arterial pressure (MAP) at rest and after resistance training. Twenty young men (age = 23.4 ± 4.
View Article and Find Full Text PDFRare bilateral vascular variations of the upper limb: a cadaveric case study.
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Centre for Human Anatomy Education, Department of Anatomy and Developmental Biology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.
Arterial variations in the upper limb are of significant clinical importance, especially in procedures such as venepunctures, coronary artery bypass grafts, trauma reconstructive surgeries, brachial plexus nerve blocks, and breast reconstructions. This report presents previously undocumented arterial variations in the upper limbs in a 95-year-old female cadaveric donor. We observed bilateral superficial ulnar arteries originating at the cubital fossa, deviating from the previously reported origin at the proximal brachial artery.
View Article and Find Full Text PDFAssessment of knowledge, attitudes, and practices regarding air pollution among traffic polices in Dhaka city, Bangladesh: a cross-sectional study.
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Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Background: The increasing number of motor vehicles in Dhaka city is contributing to a rise in air pollution. Prolonged exposure to vehicle emissions has led to various health issues for everyone, but traffic policies might be particularly affected. This study aims to evaluate their knowledge, attitudes, and practices regarding air pollution, with the goal of raising awareness and promoting healthier practices to mitigate the adverse effects of pollution.
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