AI Article Synopsis
- The initial phases of molecular self-assembly are crucial for determining the purity and properties of organic materials.
- This review highlights the importance of organic mesoscale clusters in the nucleation process and examines how their properties can be affected by sample treatment.
- It discusses various detection methods used in research, such as light scattering and microscopy, and emphasizes the potential of these clusters to aid in discovering new crystal forms, especially for complex pharmaceutical ingredients.
Article Abstract
The early stages of the molecular self-assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X-ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large-molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.
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| http://dx.doi.org/10.1002/anie.202312100 | DOI Listing |
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