AI Article Synopsis
- Palpebral congenital melanocytic nevi (PCMN) are rare skin lesions on the eyelids that can pose cosmetic, psychological, and health risks, leading to a lack of consensus in treatment approaches.
- A systematic review conducted from October 2022 to April 2023 analyzed various studies on PCMN treatments, focusing on their effectiveness, safety, and patient satisfaction.
- Findings indicated that surgical procedures like excision are generally effective for treating PCMN; however, outcomes vary significantly, highlighting the need for more research to identify optimal treatment strategies.
Article Abstract
Purpose: Palpebral congenital melanocytic nevi (PCMN) is a rare congenital skin lesion affecting the eyelids that can lead to cosmetic and psychological concerns and potential health risks such as malignancy. Several authors have analyzed therapeutical strategies to treat PCMN. However, there was no consensus in the literature. This systematic review aimed to evaluate the effectiveness, safety, and success of treatments of PCMN.
Methods: We conducted a systematic review following PRISMA guidelines from October 2022 to April 2023. We included all types of study designs that described or compared PCMN treatments and interventions, as well as histology, recurrence, adverse events, patient satisfaction, and malignant transformation. The search strategy was based on specific search words through the following databases: PubMed, Embase, Latin American and Caribbean Health Sciences Literature (Lilacs), Web of Science, and Scopus. Ongoing studies and gray literature studies were included.
Results: We analyzed 25 case reports with 148 participants. The effectiveness, success, and satisfaction with various treatments for PCMN depend on the specific treatment method and the individual patient's case.
Conclusions: Most of the studies showed that surgical procedures (exeresis) are able to treat PCMN in the eyelid. The variability in outcomes emphasizes the importance of further research to better understand the most effective and safe approaches for treating congenital melanocytic nevi.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691178 | PMC |
| http://dx.doi.org/10.1590/acb384823 | DOI Listing |
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- * The condition is usually fatal if symptoms appear, with a high chance of the brain lesions becoming malignant, especially in those with larger skin nevi.
- * Current treatments focus on palliative care and aim to manage symptoms, as there is no cure, highlighting the need for ongoing research to develop effective therapies and address this critical medical gap.
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