AI Article Synopsis

  • Naganishia albida is a type of saprophytic fungus, rarely associated with human infections, and this report details a unique case of cutaneous cryptococcosis in an older male after skin trauma.
  • A literature review identified only six similar cases, all male and aged between 14 and 86, with some patients having underlying skin conditions and other immunosuppressive factors.
  • The presentation of skin lesions varied widely, and while most patients had negative serum cryptococcal antigen tests, diagnoses were confirmed through fungal cultures, with insufficient data on the best antifungal treatments and their effects.

Article Abstract

Naganishia albida (Cryptococcus albidus) is considered saprophytic fungi, and is rarely reported as a human pathogen. Cutaneous infections caused by non-neoformans cryptococcus are rare. We describe a case of an immunocompetent older male with cutaneous cryptococcosis caused by Naganishia albida following skin trauma, and conduct a literature review in PubMed, Lilacs, and Embase. Only six previous similar reports were found. The seven cases (including ours) were widely distributed geographically (Brazil, the US, the UK, Hungary, South Korea, and Iran), all males, and their ages varied, ranging from 14 to 86 years. Four individuals had underlying skin diseases (Sezary Syndrome, psoriasis, and skin rash without etiology) plus potentially immunosuppressive underlying conditions (diabetes mellitus, kidney transplantation, and the use of etanercept, adalimumab, and methylprednisolone). Cutaneous presentation was polymorphic, with lesions characterized as warts, ulcers, plaques, and even macules. Two patients presented disseminated disease. Serum cryptococcal antigen was negative in six patients, and diagnosis was made by fungal culture in all. There is a lack of data on optimal antifungal treatment and outcomes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10703498PMC
http://dx.doi.org/10.1590/S1678-9946202365060DOI Listing

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  • A literature review identified only six similar cases, all male and aged between 14 and 86, with some patients having underlying skin conditions and other immunosuppressive factors.
  • The presentation of skin lesions varied widely, and while most patients had negative serum cryptococcal antigen tests, diagnoses were confirmed through fungal cultures, with insufficient data on the best antifungal treatments and their effects.
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