AI Article Synopsis
- Gastruloids develop their structure and shape through the biochemical and mechanical activities of cells, which influence the forces and material changes needed to transform simple shapes into complex tissues.
- This Perspective emphasizes the importance of mechanobiology, a field studying how mechanical forces affect cell and tissue behavior, in understanding the gastruloid development process.
- Moreover, the insights gained from studying gastruloids could enhance our understanding of mechanobiology and its role in living systems.
Article Abstract
Gastruloids acquire their organization and shape through cell biochemical and mechanical activities. Such activities determine the physical forces and changes in material properties that transform simple spherical aggregates into organized tissues. In this Perspective, we discuss why the concepts and approaches of mechanobiology, a discipline that focuses on cell and tissue mechanics and its contribution to the organization and functions of living systems, are essential to the gastruloid field and, in turn, what gastruloids may teach us about mechanobiology.
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| http://dx.doi.org/10.1042/ETLS20230081 | DOI Listing |
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