AI Article Synopsis
- - This study discovered that Ir(III)-Pt(IV) heterometallic conjugates can be activated by light to release therapeutic agents, specifically oxaliplatin and Ir, within just 3 minutes.
- - The conjugates were shown to induce cell death, specifically apoptosis and immunologic cell death, by binding to DNA and generating reactive oxygen species when exposed to light.
- - Overall, the research advances the development of innovative photoactivatable agents aimed at improving cancer treatment strategies.
Article Abstract
For the first time, this study reported the photoactivatable activity of Ir(III)-Pt(IV) heterometallic conjugates, which were stable in the dark and activated to release oxaliplatin and Ir within 3 min of irradiation. The conjugates induced apoptosis and immunologic cell death through Pt-DNA binding and reactive oxygen species generation upon irradiation. This work developed photoactivatable heterometallic agents for anticancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3cc04938h | DOI Listing |
Publication Analysis
Top Keywords
iriii-ptiv heterometallic
8
heterometallic conjugates
8
anticancer therapy
8
highly photoactive
4
photoactive iriii-ptiv
4
conjugates anticancer
4
therapy time
4
time study
4
study reported
4
reported photoactivatable
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!