AI Article Synopsis
- - Most cases of malignant external otitis (MEO) are linked to bacterial infections, while fungal infections are possible but very rare and hard to diagnose using standard microbiological methods.
- - In this case, two patients were successfully diagnosed with fungal malignant external otitis (FMEO) using metagenomic Next-Generation Sequencing (mNGS) and treated with surgery and voriconazole, although their antifungal treatment was initially delayed due to negative culture results.
- - The study suggests that mNGS can be a valuable tool for diagnosing FMEO in patients, particularly when traditional microbiological tests fail to identify the cause of the infection.
Article Abstract
Background: Most of malignant external otitis (MEO) cases reported in the literature are attributed to . Fungal infections in MEO are also likely but extremely rare. And conventional microbiology tests is difficult to diagnose.
Case Description: Two patients were diagnosed with Fungal malignant external otitis (FMEO) due to by metagenomic Next-Generation Sequencing (mNGS) and recovered after comprehensive treatment including operation and voriconazole. The antifungal treatment was delayed due to repeated cultures of secretions being negative and pathological examination showed granulation tissue proliferation with extensive neutrophil infiltration.
Conclusion: mNGS might be helpful for patients suspected with FMEO, especially when conventional microbiology tests were negative.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694228 | PMC |
| http://dx.doi.org/10.3389/fcimb.2023.1236414 | DOI Listing |
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