The bioinspired and stereoselective synthesis of the furo[3,2-] furan lactone (-)-protulactone A and the dioxabicyclo[3.3.1]nonane lactone (+)-protulactone B has been achieved based on the chiron approach. The synthesis features the utilization of a number of one-pot, sequential transformations, including a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a one-pot sequence cross-metathesis/acetonide deprotection/O-Michael addition/lactonization to streamline the synthesis route and avoid the tedious work of product purification. Synthetic protulactones and their analogues were evaluated for their antiproliferative activity against selected tumor cell lines (MCF-7 and Capan 2) and showed minor cytotoxicity.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d3ob01708g | DOI Listing |
Luminescence
January 2025
Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Herein, highly fluorescent sulfur and nitrogen co-doped carbon dots (N, S-CDs) had been employed as a fluorescent probe to analyze Cu in drinking water. The biogenic creatinine is known to form a stable complex with Cu; hence, it was rationally selected as a bioinspired nitrogen substrate for the first time to enhance N, S-CDs selectivity towards Cu. Moreover, the literature was surveyed to guide the selection of sulfur and carbon sources to optimize N, S-CDs quantum yield (QY), so thiourea and disodium edetate are co-carbonized with biogenic creatinine at 270°C for 40 min and characterized using different techniques.
View Article and Find Full Text PDFEnviron Res
January 2025
College of Chemistry, Liaoning University, Shenyang 110036, P. R. China; Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Yingkou Institute of Technology, Yingkou 115014, P. R. China. Electronic address:
Basic dyes are highly toxic and have adverse effects on humans such as accelerated heart rate, shock, cyanosis, and tissue necrosis upon ingestion or skin contact. Efficient removal of basic dye pollutants from wastewater is therefore essential for the protection of the environment and human health. Biomolecules exhibit excellent dye removal performance in terms of removal capacity, selectivity, and rate.
View Article and Find Full Text PDFSmall
January 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Polymer composite materials encounter considerable challenges in sustaining superior tribological properties at high rotational speeds. Inspired by the microstructure of dragonfly wings, a novel thermally stable and ambient pressure curing poly(urea-imide) resin (PURI) with excellent tribological properties has been eco-friendly synthesis using bio-based greener solvents. Furthermore, The PURI composites enhanced with polyether ether ketone (PEEK) and Polytetrafluoroethylene (PTFE) blended fabrics demonstrate excellent mechanical, with tensile strengths exceeding 175 MPa.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, Geneva CH-1211, Switzerland.
Moth-eye nanostructures, known for their biological antireflective properties, are formed by a self-assembly mechanism. Understanding and replicating this mechanism on artificial surfaces open avenues for the engineering of bioinspired multifunctional nanomaterials. Analysis of corneal nanocoatings from butterflies of the genus reveals a variety of nanostructures with uniformly strong antiwetting properties accompanied by varying antireflective functionalities.
View Article and Find Full Text PDFMolecules
December 2024
Department of Biology, University of Naples Federico II, Via Cinthia, 80126 Naples, Italy.
species constitute the most common cause of fungal infections in humans; the emergence of resistance and biofilm formation by species further threaten the limited availability of antifungal agents. Over the past decade, . has caused significant outbreaks worldwide and has emerged as a human pathogenic fungus that causes diseases ranging from superficial to life-threatening disseminated infections.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!