AI Article Synopsis
- Trained immunity improves immune responses to infections and vaccines.
- Pre-vaccination with bacteria-derived outer-membrane vesicles boosts tumor vaccination efficacy by activating immune signaling.
- This enhanced immune response leads to better T-cell activation and greater protection against tumors in experimental models.
Article Abstract
Trained immunity enhances the responsiveness of immune cells to subsequent infections or vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer-membrane vesicles, which contain large amounts of pathogen-associated molecular patterns, can be used to potentiate, and enhance, tumour vaccination by trained immunity. Intraperitoneal administration of these outer-membrane vesicles to mice activates inflammasome signalling pathways and induces interleukin-1β secretion. The elevated interleukin-1β increases the generation of antigen-presenting cell progenitors. This results in increased immune response when tumour antigens are delivered, and increases tumour-antigen-specific T-cell activation. This trained immunity increased protection from tumour challenge in two distinct cancer models.
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| http://dx.doi.org/10.1038/s41565-023-01553-6 | DOI Listing |
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