AI Article Synopsis
- * The cytotoxic effects of the crude extracts and isolated compounds were tested on four different cell lines: Caco-2, HeLa, MCF-7, and OVK-18.
- * Compound 1 was toxic to MCF-7 cells, while compound 2 effectively targeted Caco-2 and OVK-18 cells, and compound 3 showed strong activity against OVK-18 cells, highlighting their potential for future pharmaceutical use.
Article Abstract
Three prenylated flavonoids (1-3) were isolated from Tetragonula biroi propolis. The structures of the isolated compounds were characterized by NMR, IR, and UV spectroscopic and mass spectrometric analyses. The cytotoxicity activity of the crude extracts, fractions and the isolated compounds were established against four cell lines such as Caco-2, HeLa, MCF-7, and OVK-18. Among the tested compounds, compound 1 showed cytotoxicity activity against MCF-7 cell lines, whereas compound 2 showed good activity against Caco-2 and OVK-18 cell lines with IC values of 14.73 and 14.44, respectively. Moreover, compound 3 exhibited strong activity against OVK-18 cell lines. These findings contribute to the phytochemical understanding of the T. biroi propolis, and their cytotoxicity effects for future pharmaceutical purposes.
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| http://dx.doi.org/10.1016/j.toxicon.2023.107352 | DOI Listing |
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