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| http://dx.doi.org/10.4103/1673-5374.387987 | DOI Listing |
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Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, L., in Long COVID and Other Conditions Involving Cognitive Impairment.
Int J Mol Sci
October 2024
Institute for Neuro-Immune Medicine-Clearwater, Clearwater, FL 33759, USA.
The European olive tree, L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. This review examines the evidence for the anti-inflammatory and neuroprotective actions of olive polyphenols and their potential in the treatment of long COVID and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS).
View Article and Find Full Text PDFPro-inflammatory protein S100A9 targeted by a natural molecule to prevent neurodegeneration onset.
Int J Biol Macromol
September 2024
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy. Electronic address:
Accumulation of the pro-inflammatory protein S100A9 has been implicated in neuroinflammatory cascades in neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD). S100A9 co-aggregates with other proteins such as α-synuclein in PD and Aβ in AD, contributing to amyloid plaque formation and neurotoxicity. The amyloidogenic nature of this protein and its role in chronic neuroinflammation suggest that it may play a key role in the pathophysiology of these diseases.
View Article and Find Full Text PDFTransgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components.
Mech Ageing Dev
August 2024
Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Article Synopsis
- * Most research has focused on protecting brain cells, but it's important to look at the early stages of brain inflammation too.
- * Some foods, like those in the Mediterranean diet, and certain plant extracts might help reduce inflammation and support brain health, offering new ways to treat these diseases.
Olive oil tyrosols reduce α-synuclein aggregation and after ingestion in a Parkinson's model.
Food Funct
July 2024
Departamento de Bioquímica y Biología Molecular A, Unidad Docente de Biología, Facultad de Veterinaria. Regional Campus of International Excellence "Campus Mare Nostrum". Universidad de Murcia, Murcia, Spain.
Parkinson's disease is the neurodegenerative motor disorder with the highest incidence worldwide. Among other factors, Parkinson's disease is caused by the accumulation of α-synuclein aggregates in a patient's brain. In this work, five molecules present in the diet are proposed as possible nutraceuticals to prevent and/or reduce the formation of α-synuclein oligomers that lead to Parkinson's disease.
View Article and Find Full Text PDFHydroxytyrosol and Parkinson's disease: protective actions against alpha-synuclein toxicity.
Neural Regen Res
July 2024
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain; and Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
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