Purpose: In this study, we aimed to compare the results of Karidakis flap reconstruction with crystallized phenol in pilonidal sinus treatment.
Methods: 216 patients treated for pilonidal sinus disease with the researched methods between June 2016 and July 2019 were included in the study.
Results: 142 (65.7%) of the patients were treated with the KFR technique and 74 (34.3%) with the crystallized phenol method. Of the patients included in the study, 157 (72.7%) were male, and 59 (27.3%) were female. The mean age was calculated as 24.89 (± 8.4). The mean hospital stay in the KFR group was 1.21 (± 0.4) days. The mean time to return to work was 2.79 (± 1.03) days in the phenol group and 15.35 (± 3.39) days in the KFR group. In 4 (5.4%) patients, the improvement could not be achieved despite multiple sessions of phenol administration, and the procedure was considered unsuccessful. Recurrence occurred in 6 patients (4.22%) in the KFR group. The mean follow-up period was 13.44 (11-16) months in the KFR group and 13.67 (11-16) months in the phenol group. CONCLUSİON: It is thought that phenol administration can be applied in selected single-pit cases with high success, low complications, hospitalization, and early return to work. While the KFR method's lower recurrence rates are advantageous, it was noteworthy that the complication rates were higher.
Key Words: Crystallized phenol, Karydakis flap reconstruction, Pilonidal sinus disease.
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Biofilm
June 2025
Centre of Biological Engineering, LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Bacterial biofilms formed by and pose significant challenges in treating cystic fibrosis (CF) airway infections due to their resistance to antibiotics. New therapeutic approaches are urgently needed to treat these chronic infections. This study aimed to investigate the antibiofilm potential of various plant extracts, specifically targeting mucoid and small colony variants of and and strains.
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January 2025
Microbial Biotechnology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitaetsstrasse 150, 44780 Bochum, Germany.
4-Phenol oxidases are proposed to be involved in the utilization of lignin-derived aromatic compounds. While enzymes with selectivity towards 4-hydroxyphenyl and guaiacyl motifs are well described, we identified the first syringyl-specific oxidase from Streptomyces cavernae (Sc4ASO) only very recently. Here, in-depth studies were conducted to unravel the molecular origins of the outstanding selectivity of Sc4ASO.
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January 2025
College of Chemical Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Interfacial solar vapor generation (ISVG) accompanied by photocatalytic degradation holds immense potential to mitigate water scarcity and pollution. Distinct from the two detached functional components (photothermal agent and photocatalyst) in a conventional evaporator, in this study, an all-in-one photothermal/catalytic agent, nitrogen-containing honeycomb carbon nanosheets (NHC), was engineered for synergistic high-efficiency steam generation and photocatalysis functions. It was demonstrated that the superoxide radical generated on the surface of NHC conferred its catalytic activity to the photodegradation of organic pollutants under full solar spectrum irradiation.
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January 2025
Instituto de Química, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas 37130-000, MG, Brazil.
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January 2025
Departamento de Ingeniería Química y de Materiales, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Water pollution, resulting from industrial effluents, agricultural runoff, and pharmaceutical residues, poses serious threats to ecosystems and human health, highlighting the need for innovative approaches to effective remediation, particularly for non-biodegradable emerging pollutants. This research work explores the influence of shape-controlled nanocrystalline titanium dioxide (TiO NC), synthesized by a simple hydrothermal method, on the photodegradation efficiency of three different classes of emerging environmental pollutants: phenol, pesticides (methomyl), and drugs (sodium diclofenac). Experiments were conducted to assess the influence of the water matrix on treatment efficiency by using ultrapure water and stormwater (basic) collected from an urban drainage system as matrices.
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