Molecular clips with spatially proximal urea residues for efficient transmembrane co-transport of H/Cl ions.

We report the design of bis(urea) functionalized amphiphilic molecular clips . 1a-1e to achieve efficient transmembrane co-transport of H/Cl ions. The most promising molecule 1a demonstrated a low nanomolar EC value (6.96 nM) to co-transport H/Cl ions a carrier-mediated pathway and showed selective toxicity against cancerous HeLa cells as a result.