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Explainable Machine Learning to Predict Treatment Response in Advanced Non-Small Cell Lung Cancer.
JCO Clin Cancer Inform
January 2025
Emory University School of Medicine, Atlanta, GA.
Purpose: Immune checkpoint inhibitors (ICIs) have demonstrated promise in the treatment of various cancers. Single-drug ICI therapy (immuno-oncology [IO] monotherapy) that targets PD-L1 is the standard of care in patients with advanced non-small cell lung cancer (NSCLC) with PD-L1 expression ≥50%. We sought to find out if a machine learning (ML) algorithm can perform better as a predictive biomarker than PD-L1 alone.
View Article and Find Full Text PDFIntroduction: Drinking contaminated water is a significant cause of mortality and morbidity in Sub-Saharan Africa, where access to safe drinking water is limited. Although numerous studies have investigated the bacteriological quality of drinking water in Ethiopia, their findings have been inconsistent and varied, hindering the implementation of effective water quality monitoring. Moreover, there is a lack of nationwide assessment of the bacteriological quality of drinking water in Ethiopia.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Queen Mary University of London, London, United Kingdom.
Background: Various explanations have been proposed for how hearing impairment might be associated with increased risk of dementia. Several theories have proposed direct links with Alzheimer's disease (AD) neuropathology, either due to shared aetiology (i.e.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Hallym University, Chuncheon, Gangwon-do, Korea, Republic of (South).
Background: In patients with mild cognitive impairment (MCI), the presence or absence of memory deficits is associated with divergent clinical presentations, etiologies, and prognostic outcomes. These differences may also manifest in additional neurologic signs beyond cognitive impairments and are often reflected in distinct magnetic resonance imaging (MRI) profiles. Gait is one of the clinical characteristics that reflects brain function along with cognitive function.
View Article and Find Full Text PDFAccurate diagnosis of heart failure and improved perioperative outcomes.
Br J Anaesth
January 2025
Department of Anesthesiology, Critical Care and Burn Unit, University Saint-Louis-Lariboisière Hospital, AP-HP, Paris, France; Université de Paris Cité, Paris, France; INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Université de Paris Cité, Paris, France; Fédération Hopsitalo-Universitaire (FHU) Precision Medicine for a Comprehensive Care of Critically ill patients, Université de Paris Cité, Paris, France; Cardiovascular and Renal Clinical Trialists, Nancy, France.
With an ageing world population and increasing prevalence, heart failure is increasingly frequent as a comorbidity in operative patients, and its accurate preoperative diagnosis is essential to improve postoperative prognosis in patients undergoing noncardiac surgery. Use of electronic health records to assist in the accuracy of diagnosis and definition of an adjudicated heart failure reference standard could help guide intraoperative practice and improve outcomes in patients with heart failure.
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