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| http://dx.doi.org/10.1001/jamainternmed.2023.6428 | DOI Listing |
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Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine.
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Colostrum, the initial mammary secretion produced by various mammals following birth, is a conduit for maternal immunity transfer in diverse mammalian species. Concurrently, many cellular processes are occurring in the neonatal small intestine to prepare it to receive molecular signals from a superfood essential for the neonate's health and development. During the prepartum colostrum secretion, the newborn intestine undergoes transient alterations in the intestinal barrier, primarily regulating immunoglobulin absorption.
View Article and Find Full Text PDFIntroduction: Transgender individuals may face familial and social hostility, leading to distress that significantly affects their well-being. This study aims to understand life course challenges experienced by transgender people since childhood.
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Extensive homologous recombination safeguards oocyte genome integrity in mammals.
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MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, No.866 Yuhangtang Road, 310058, Hangzhou, China.
Meiosis in mammalian oocytes is interrupted by a prolonged arrest at the germinal vesicle stage, during which oocytes have to repair DNA lesions to ensure genome integrity or otherwise undergo apoptosis. The FIRRM/FLIP-FIGNL1 complex dissociates RAD51 from the joint DNA molecules in both homologous recombination (HR) and DNA replication. However, as a type of non-meiotic, non-replicative cells, whether this RAD51-dismantling mechanism regulates genome integrity in oocytes remains elusive.
View Article and Find Full Text PDFBarriers to medication administration error reporting in a tertiary hospital in Lebanon.
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Rapid review to inform the selection of a set of brief set of universal indicators for use in large-scale cross-national ageism research.
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Objectives: Ageism occurs across the world, with negative consequences for individuals and societies. In 2016, WHO received a mandate from its Member States to lead the global campaign to combat ageism. To monitor, evaluate, and build evidence for reducing ageism, the availability of a brief, reliable and valid set of indicators of ageism experiences that can be used globally is essential.
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